Preferred Label : TRPV6 Calcium Channel Inhibitor SOR-C13;
NCIt related terms : SOR-C13;
NCIt definition : An inhibitor of transient receptor potential cation channel vanilloid family member
6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel
inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing
tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT)
transcription complex which may result in an inhibition of calcium-dependent cancer
cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6.
The TRPV6 ion channel plays a key role in calcium homeostasis and is highly selective
for calcium compared to other cations; it is overexpressed in a variety of tumors
and initiates tumor cell growth, proliferation and metastases.;
UNII : C79B5A73C4;
InChIKey : LGANPTNILMNMES-TVNHODDRSA-N;
CAS number : 1187852-48-7;
Molecule name : SOR-C13;
NCI Metathesaurus CUI : CL435782;
Origin ID : C101525;
UMLS CUI : C3640131;
Semantic type(s)
- UMLS correspondences (same concept)
- SOR-C13 [MeSH Supplementary Concept]
- concept_is_in_subset
