Preferred Label : Tocotrienol-rich Fraction;
NCIt synonyms : TRF;
NCIt definition : An orally available nutritional supplement containing high amounts of the vitamin
E family member tocotrienol with antioxidant, hypolipidemic and potential immunomodulating
and antiproliferative activity. Upon oral administration, tocotrienol-rich fraction
(TRF) accumulates in tumor cells and induces cell cycle arrest, programmed cell death,
and inhibits tumor cell proliferation. In addition, this agent suppresses 3-hydroxy-3-methylglutaryl
coenzyme A (HMG CoA) reductase activity and inhibits angiogenesis. Rice bran oil,
palm oil and annatto seed oil are common sources of TRF.;
NCI Metathesaurus CUI : CL435775;
Origin ID : C101518;
UMLS CUI : C3540580;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
