Preferred Label : Gamma-delta Tocotrienol;
NCIt synonyms : gdT3; GDT;
NCIt definition : An orally available nutritional supplement containing the gamma and delta forms of
the vitamin E family member tocotrienol, with hypocholesterolemic, antithrombotic,
antioxidant, and potential antineoplastic activity. Upon oral administration, gamma-delta
tocotrienol accumulates in cancer cells and may exert their anti-cancer activity in
part through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase downregulation
and/or degradation, cell cycle arrest, and induction of caspase-mediated apoptosis.
In addition, this agent may inhibit angiogenesis partially through the blockage of
vascular endothelial growth factor receptor (VEGFR) and the inhibition of tumor cell-induced
vessel formation. Altogether, this may result in the inhibition of tumor cell growth.
Further, this agent prevents free radical formation and inhibits lipid peroxidation.
Tocotrienols contain 3 double bonds, absent in tocopherols, on its farnesyl isoprenoid
side chain that likely contribute to its anti-cancer activities.;
NCI Metathesaurus CUI : CL435774;
Origin ID : C101517;
UMLS CUI : C3640123;
Semantic type(s)
- concept_is_in_subset
