Preferred Label : Ubenimex;
NCIt synonyms : Bestatin; N-[(2S,3R)-4-phenyl-3-amino-2-hydroxybutyryl]-L-leucine; [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine; [S-(R*,S*)]-N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine;
NCIt related terms : L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-;
NCIt definition : A microbial metabolite and dipeptide with potential immunomodulatory and antitumor
activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and
leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell
adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially
attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte,
macrophage and bone marrow stem cell as well as stimulates release of interleukin-1
and -2, thus further enhances its antitumor activity.;
UNII : I0J33N5627;
InChIKey : VGGGPCQERPFHOB-RDBSUJKOSA-N;
CAS number : 58970-76-6;
Molecule name : NK 421;
Chemical formula : C16H24N2O4;
NSC code : 265489;
Codes from synonyms : NSC0265489; 30432;
Origin ID : C1015;
UMLS CUI : C0053355;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
