Preferred Label : CD-expressing Bifidobacterium APS001F;
NCIt definition : A recombinant anaerobic bacterium, Bifidobacterium longum, encoding the cytosine deaminase
(CD) gene with potential antineoplastic adjuvant activity. Upon injection, the CD-expressing
bifidobacterium preferentially localizes and grows in the hypoxic environment of the
tumor and expresses CD, an enzyme that catalyzes the intracellular conversion of the
prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). Upon
administration of 5-FC, and subsequent localized conversion into 5-FU and its cytotoxic
active metabolites, the tumor is specifically exposed to cytotoxic agents while the
exposure to normal tissues is minimal.;
Molecule name : APS001F;
NCI Metathesaurus CUI : CL435547;
Origin ID : C101367;
UMLS CUI : C3640095;
Semantic type(s)
- concept_is_in_subset
