NCIt synonyms : Prostate Cancer Hereditary Type 1 Gene; PRCA1; RNS4; Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) wt Allele;
NCIt definition : Human RNASEL wild-type allele is located in the vicinity of 1q25 and is approximately
16 kb in length. This allele, which encodes 2-5A-dependent ribonuclease protein, is
involved in the antiviral response. Mutation of the gene is associated with prostate
cancer hereditary type 1.;
NCIt note : A SNP for the RNASEL gene may be a prognostic marker for prostate cancer. (Cancer
Epidemiol Biomarkers Prev. 2011; 20: 1928-1936.);