Preferred Label : Valecobulin;
NCIt synonyms : (S)-N-(4-(3-(1H-1,2,4-Triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl)thiazol-2-yl)-2-amino-3-methylbutanamide
Hydrochloride; Tubulin Polymerization Inhibitor CKD-516;
NCIt definition : A benzophenone derivative and water soluble valine prodrug of the tubulin binding
agent S516, with potential tubulin-inhibiting, vascular-disrupting and antineoplastic
activity. Upon administration, valecobulin is converted into its active metabolite
S-516 that binds to tubulin and prevents its polymerization in tumor blood vessel
endothelial cells and tumor cells. This blocks the formation of the mitotic spindle
and leads to cell cycle arrest at the G2/M phase. As a result, this agent disrupts
the tumor vasculature and tumor blood flow, deprives tumor cells of nutrients and
induces tumor cell apoptosis. In addition, this agent has a direct cytotoxic effect
on tumor cells by inhibiting tubulin polymerization.;
UNII : P48P97V001;
InChIKey : UKKRUIXIDCWALA-QFIPXVFZSA-N;
CAS number : 1188371-47-2;
Molecule name : CKD-516;
Origin ID : C101264;
UMLS CUI : C3640064;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
