Sofosbuvir - CISMeF

Preferred Label : Sofosbuvir;

NCIt synonyms : L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl Ester;

NCIt definition : An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.;

UNII : WJ6CA3ZU8B;

InChIKey : TTZHDVOVKQGIBA-IQWMDFIBSA-N;

CAS number : 1190307-88-0;

Molecule name : GS-7977; PSI-7977;

Chemical formula : C22H29FN3O9P;

PubMed : 20845908;

Details

Origin ID

C101263;

UMLS CUI

C2976303;

Automatic exact mappings (from CISMeF team)
- Product containing sofosbuvir (medicinal product) [SNOMED CT concept]
CISMeF manual mappings
- Sofosbuvir [MeSH Descriptor]
- Sofosbuvir (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Sofosbuvir [MeSH concept]
- Sofosbuvir [LOINC component]
- Sofosbuvir [ICD-11 Extension code]
- Sofosbuvir [SMS substance]
- l-alanine, n-[[p(s),2'r]-2'-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl]-,1-methylethyl ester [Substance BNPC]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sofosbuvir (medicinal product) [SNOMED CT concept]
- Sofosbuvir [MeSH Descriptor]
- Sofosbuvir [MeSH concept]
- Sofosbuvir [LOINC component]
- Sofosbuvir (substance) [SNOMED CT concept]
- l-alanine, n-[[p(s),2'r]-2'-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl]-,1-methylethyl ester [Substance BNPC]
- sofosbuvir [ATC Code]
Validated automatic mappings to BTNT
- sofosbuvir [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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