NCIt definition : An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase
inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir
is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate,
which is then converted into the active triphosphate nucleotide that inhibits the
NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent
RNA polymerase, is essential for the replication of the viral HCV RNA genome.;
UNII : WJ6CA3ZU8B;
InChIKey : TTZHDVOVKQGIBA-IQWMDFIBSA-N;
CAS number : 1190307-88-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1190307-88-0
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