Preferred Label : Elsiglutide;
NCIt definition : A synthetic glucagon-like peptide-2 (GLP-2) analogue with potential antidiarrheal
and intestinotrophic activities. Upon subcutaneous administration, elsiglutide, a
39 amino acid polypeptide, binds to GLP-2 receptors and thereby promotes proliferation
of epithelial cells. Regeneration of endothelial cells damaged during chemotherapy
may prevent or decrease chemotherapy-induced diarrhea. In addition, elsiglutide may
prevent chemotherapy-induced intestinal injury. GLP-2, a peptide hormone primarily
produced in the small intestines in response to food, plays a key role in intestinal
epithelial growth, metabolism and regeneration of epithelial cells.;
UNII : SC864Q40VB;
CAS number : 914009-84-0;
Molecule name : ZP1846;
NCI Metathesaurus CUI : CL433984;
Origin ID : C101131;
UMLS CUI : C3639997;
Semantic type(s)
- concept_is_in_subset
