" /> Nafazatrom - CISMeF





Preferred Label : Nafazatrom;

NCIt synonyms : 3H-pyrazol-3-one,2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl); 1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one;

NCIt definition : A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of prostacyclin (prostaglandin I2; PGI2) and prevents intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. An elevated level of PGI2 prevents aggregation of platelets; subsequently it decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis.;

UNII : K94216221B;

InChIKey : ULPLLIRKFGAHTA-UHFFFAOYSA-N;

CAS number : 59040-30-1;

Molecule name : Bay-g 6575; Bay g 6575;

Chemical formula : C16H16N2O2;

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25/05/2025


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