Preferred Label : Ammonium Trichlorotellurate;
NCIt synonyms : Tellurate(1-), trichloro[1,2-ethanediolato(2-)-kappa-O,kappa-O']-,ammonium, (SP-5-22)-;
NCIt definition : A synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with
immunostimulatory and anti-hair loss properties. Ammonium trichlorotellurate induces
production of colony stimulating factor (CSF), interleukin-2 (IL-2), and IL-2 receptors
by increasing the calcium ion influx through the cell membrane and subsequently exerts
its immunostimulatory effects through the CSF-mediated increase in macrophage/granulocytes.
This agent is also a potent inducer of interferon and a spectrum of cytokines such
as IL-1, IL-6, and tumor necrosis factor (TNF). In animal studies, ammonium trichlorotellurate
exerts its anti-hair loss effect by inducing anagen and obstructing spontaneous catagen
via promoting follicular keratinocyte proliferation and interfering with terminal
differentiation, respectively.;
NCIt note : Although its CN is AS101, it's not the same as 4-Arsanilic acid, NSC 2023, (C29883).;
UNII : 708681952A;
CAS number : 106566-58-9;
Drug name : Ossirene;
Molecule name : AS-101; IVX-Q-101;
NSC code : 618654;
Origin ID : C1006;
UMLS CUI : C0052457;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
