NCIt related terms : 3-Phenylacetylamino-2,6-piperidinedione;
NCIt definition : A piperidinedione antineoplaston with potential antineoplastic activity. Antineoplaston
A10 was originally isolated from human urine but is now synthetically derived. This
agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction
of mitosis, and decreased protein synthesis. Antineoplaston A10 may also inhibit ras-oncogene
expression and activate tumor suppressor gene p53, leading to cell differentiation
and apoptosis. (NCI04);
UNII : 16VY3TM7ZO;
InChIKey : OQGRFQCUGLKSAV-JTQLQIEISA-N;
CAS number : 91531-30-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 91531-30-5
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