Antineoplaston A10

Preferred Label : Antineoplaston A10;

NCIt synonyms : 3-Phenylacetylamino-2, 6-piperidinedione; Benzeneacetamide, N-(2,6-dioxo-3-piperidinyl)-, (S)-; A10; Atengenal;

NCIt related terms : 3-Phenylacetylamino-2,6-piperidinedione;

NCIt definition : A piperidinedione antineoplaston with potential antineoplastic activity. Antineoplaston A10 was originally isolated from human urine but is now synthetically derived. This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. (NCI04);

UNII : 16VY3TM7ZO;

InChIKey : OQGRFQCUGLKSAV-JTQLQIEISA-N;

CAS number : 91531-30-5;

NSC code : 377381; 619130;

Codes from synonyms : NSC0619130; 30663;

Details

Origin ID

C1004;

UMLS CUI

C0052080;

Automatic exact mappings (from CISMeF team)
- 3-phenylacetylamino-2,6-piperidinedione [MeSH Supplementary Concept]
- 3-phenylacetylamino-2,6-piperidinedione [MeSH concept]
- Trunk of posterior basal segmental artery [FMA entity]
Currated CISMeF NLP mapping
- antineoplaston A10 [MeSH concept]
- antineoplaston A10 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3-phenylacetylamino-2,6-piperidinedione [MeSH Supplementary Concept]
- antineoplaston A10 [MeSH concept]
- antineoplaston A10 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Antineoplaston A10/Antineoplaston AS2-1 [NCIt concept]
- Antineoplaston A10/Methotrexate [NCIt concept]

Keyword's position in hierarchy(ies) :

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