Ansamycin Antineoplastic Antibiotic

Preferred Label : Ansamycin Antineoplastic Antibiotic;

NCIt synonyms : Ansamycins; Ansamycin Antibiotics;

NCIt related terms : ansamycin;

NCIt definition : An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins and the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.;

ChEBI ID : CHEBI:22565;

Codes from synonyms : CDR0000046677;

Details

Origin ID

C1003;

UMLS CUI

C0051936;

Automatic exact mappings (from CISMeF team)
- Ansamycin [ICHI extension code]
- lactams, macrocyclic [MeSH Descriptor]
- rifabutin [MeSH Descriptor]
- rifabutin [MeSH concept]
Currated CISMeF NLP mapping
- Ansamycin [ICD-11 Extension code]
- ansamycins [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Ansamycin [ICD-11 Extension code]
- ansamycins [MeSH concept]

Keyword's position in hierarchy(ies) :

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