Preferred Label : Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes;
NCIt definition : Allogeneic tri-viral specific, adenovirus, cytomegalovirus and Epstein-Barr virus
(Adv, CMV and EBV or ACE), cytotoxic T-lymphocytes (CTLs) with potential antiviral
activity. Donor-derived T-cells were exposed to dendritic cells nucelofected with
DNA plasmids encoding Hexon and Penton (Adv), pp65 and IE1 (CMV), and LMP2, EBNA1
and BZLF1 (EBV), all are critical proteins for the proliferation of these viruses,
and subsequently maintained in the presence of interleukins 4 and 7 with a novel culture
device to expand and sustain the repertoire of CTLs. After an allogeneic hematopoietic
stem cell transplant (HSCT), infusion of these CTLs primed towards Adv, CMV and EBV
may prevent viral infection by these pathogens.;
NCI Metathesaurus CUI : CL433980;
Origin ID : C100102;
UMLS CUI : C3639094;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
