Preferred Label : Naratuximab Emtansine;
NCIt definition : An immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface
antigen CD37 and covalently linked via the uncleavable, maleimide-derived thioether-based
linker SMCC to the maytansinoid DM1, with potential pro-apoptotic and cytotoxic activities.
Upon administration of naratuximab emtansine, the antibody moiety of IMGN529 binds
to CD37 on tumor B-cells and induces an antibody-dependent cell-mediated cytotoxicity
(ADCC) and complement-dependent cytotoxicity (CDC), thereby showing pro-apoptotic
activity. In addition, after the internalization of this agent and lysosomal degradation,
the DM1 moiety binds to tubulin and inhibits tubulin polymerization and microtubule
assembly, resulting in a disruption of microtubule activity and cell division, and
eventually causing cell death in CD37-positive B-cells. CD37, a transmembrane glycoprotein,
is overexpressed in B-cell malignancies. Compared to reducible, cleavable linkers,
the non-reducible SMCC linker shows increased stability in plasma.;
UNII : WE1X5A83B9;
CAS number : 1607824-64-5;
Molecule name : IMGN529; MP-529; MP 529;
Origin ID : C100101;
UMLS CUI : C5139906;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
