Preferred Label : 3-AP/Fludarabine;
Obsolete resource : true;
NCIt synonyms : 3AP/FAMP; 3-AP Fludarabine;
NCIt definition : A combination of the thiosemicarbazone 3-aminopyridine-2-carboxaldehyde (3-AP) and
the nucleoside analogue fludarabine with antineoplastic activity. The agents in 3-AP/fludarabine,
act synergistically to inhibit the enzyme ribonucleotide reductase.. Composed of two
subunits, this enzyme catalyzes the rate-limiting step in the conversion of ribonucleotides
to deoxyribonucleotides. The 3-AP binds to and inactivates one subunit while fludarabine
binds to and inactivates the other. Fludarabine also inhibits DNA polymerase alpha
and DNA primase. At low concentrations, this agent arrests tumor cells in the S-phase
of the cell cycle; at higher concentrations, in the G0/G1 phase of the cell cycle.
(NCI04);
Concept status : Obsolete_Concept;
Origin ID : C38719;
UMLS CUI : C1328164;
Semantic type(s)
- chemotherapy_regimen_has_component
