Preferred Label : iodothyronine deiodinase type II;
MeSH note : Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone
thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine;
may contribute significantly to the relative increase in thyroidal T3 production in
patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency; RefSeq
NM_000793 (human); NM_031720 (rat); NM_010050 (mouse);
CISMeF synonym : DIO2 protein, human; Dio2 protein, mouse; Dio2 protein, rat;
MeSH synonym : type 2 selenodeiodinase; type 2 deiodinase (D2); type II 5'-deiodinase; selenodeiodinase type 2;
MeSH hyponym : iodothyronine type II deiodinase, mouse; deiodinase, iodothyronine, type II, mouse; deiodinase, iodothyronine, type II, rat; deiodinase iodothyronine type 2, rat; hdio2 protein, human; thyroxine deiodinase, type II, human; TXDI2 protein, human; D2 protein, human; deiodinase, iodothyronine, type II, human; preoptic regulatory factor 1 protein, rat; porf-1 protein, rat;
Registry Number MeSH : EC 1.11.1.-;
Is substance : O;
Origin ID : C102141;
UMLS CUI : C0531251;
MeSH indexing information
- MeSH term(s) associated for indexing
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