Anaphase-Promoting Complex-Cyclosome

Preferred Label : Anaphase-Promoting Complex-Cyclosome;

MeSH definition : An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.;

MeSH synonym : anaphase promoting complex;

Wikipedia automatic translation : Anaphase-promoting complex;

Registry Number MeSH : EC 6.3.2.19; EC 2.3.2.27;

Wikipedia link : https://en.wikipedia.org/wiki/Anaphase-promoting complex;

Is substance : O;

UNII : EC 2.3.2.27;

Details

Origin ID

D064173;

UMLS CUI

C0526999;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- anaphase-promoting complex [GO term]
Record concept(s)
- Anaphase-Promoting Complex-Cyclosome [MeSH concept]
Related MeSH Supplementary Concept(s)
- ANAPC15 protein, human [MeSH Supplementary Concept]
- CDC26 protein, S cerevisiae [MeSH Supplementary Concept]
- MND2 protein, S cerevisiae [MeSH Supplementary Concept]
- SWM1 protein, S cerevisiae [MeSH Supplementary Concept]
- emb-1 protein, C elegans [MeSH Supplementary Concept]
- hcn1 protein, S pombe [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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