Preferred Label : sterol 14-Demethylase;
MeSH definition : An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic
pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The
enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its
stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is
removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme
in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI;
and protozoa.;
MeSH synonym : 14-Demethylase, sterol; cytochrome P-450 CYP51; CYP51, cytochrome P-450; cytochrome P 450 CYP51; P-450 CYP51, cytochrome; eburicol 14 alpha-Demethylase; 14 alpha-Demethylase, eburicol; eburicol 14 alpha demethylase; sterol 14-Demethylases; 14-Demethylases, sterol; sterol 14 demethylases; lanosterol 14 alpha-Demethylase; 14 alpha-Demethylase, lanosterol; lanosterol 14 alpha demethylase; obtusifoliol 14alpha-Demethylase; 14alpha-Demethylase, obtusifoliol; obtusifoliol 14alpha demethylase; sterol 14-alpha-Demethylase; 14-alpha-Demethylase, sterol; sterol 14 alpha demethylase; CYP51 cytochrome P-450; CYP51 cytochrome P 450; cytochrome P-450, CYP51; P-450, CYP51 cytochrome; eburicol 14alpha-Demethylase; 14alpha-Demethylase, eburicol; eburicol 14alpha demethylase; sterol 14 demethylase;
Registry Number MeSH : EC 1.14.13.70;
Wikipedia link : https://en.wikipedia.org/wiki/Sterol 14-demethylase;
Is substance : O;
UNII : EC 1.14.14.154;
Origin ID : D058886;
UMLS CUI : C0064644;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
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An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic
pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The
enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its
stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is
removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme
in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI;
and protozoa.
