cathepsin K - CISMeF

Preferred Label : cathepsin K;

MeSH definition : A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.;

Registry Number MeSH : EC 3.4.22.38;

MeSH annotation : Cathepsin X, an obsolete multi-meaning term appearing in older literature goes here or at CATHEPSIN Z: check text; Cathepsin O and Cathepsin O2 in older literature go here.;

Is substance : O;

UNII : EC 3.4.22.38;

Details

Origin ID

D056657;

UMLS CUI

C0284930;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CTSK Gene [NCIt concept]
- Cathepsin k [OMIM gene]
- cathepsin K [ORDO Gene]
Indexing information
- MK 0674 [MeSH Supplementary Concept]
- N-(1-cyanocyclopropyl)-2-((4-(1,3-dimethyl-1H-indazol-5-yl)-2-methylpiperazin-1-yl)carbonyl)cyclohexanecarboxamide [MeSH Supplementary Concept]
- N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido(4,3-b)indole-2-carbonyl)cyclohexanecarboxamide [MeSH Supplementary Concept]
- ONO-5334 [MeSH Supplementary Concept]
Record concept(s)
- cathepsin K [MeSH concept]
Related MeSH Supplementary Concept(s)
- CTSK protein, human [MeSH Supplementary Concept]
- ctsk protein, mouse [MeSH Supplementary Concept]
- ctsk protein, rat [MeSH Supplementary Concept]
- procathepsin K [MeSH Supplementary Concept]
See also inter- (CISMeF)
- cathepsin K [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cathepsin K [NCIt concept]
- Cathepsin K [LOINC component]
- Cathepsin K (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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