ribosome inactivating proteins

Preferred Label : ribosome inactivating proteins;

MeSH definition : N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.;

MeSH synonym : rrna n glycosylases; glycosylase, rna; rna n glycosidase; n-glycosidase, rna; glycosidase, polynucleotide adenosine; inactivating proteins, ribosome; proteins, ribosome inactivating; rip (ribosome inactivating proteins); rna n-glycosidase; rrna n-glycosylases; n-glycosylases, rrna; polynucleotide adenosine glycosidase; adenosine glycosidase, polynucleotide; rna glycosylase; RIP Ribosome Inactivating Proteins;

Registry Number MeSH : EC 3.2.2.22;

Is substance : O;

UNII : EC 3.2.2.22;

Details

Origin ID

D054788;

UMLS CUI

C0140649;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Ribosomal ribonucleic acid N-glycosylase (substance) [SNOMED CT concept]
Indexing information
- snowdrop lectin [MeSH Supplementary Concept]
- viscotoxin [MeSH Supplementary Concept]
Pharmacological action(s)
- protein synthesis inhibitors [MeSH Descriptor]
Record concept(s)
- ribosome inactivating proteins [MeSH concept]
Related MeSH Supplementary Concept(s)
- ME1 N-glycosidase [MeSH Supplementary Concept]
- MMC protein, momordica charantia [MeSH Supplementary Concept]
- VAA-I protein, viscum album [MeSH Supplementary Concept]
- amaranthin protein, amaranthus [MeSH Supplementary Concept]
- balsamin [MeSH Supplementary Concept]
- lychnin [MeSH Supplementary Concept]
- mistletoe lectin II [MeSH Supplementary Concept]
- mistletoe lectin III [MeSH Supplementary Concept]
- nigrin b protein, sambucus nigra [MeSH Supplementary Concept]
- pokeweed lectin C [MeSH Supplementary Concept]
- pokeweed lectin D [MeSH Supplementary Concept]
- sambucus nigra lectins [MeSH Supplementary Concept]
- velutin protein, flammulina velutipes [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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