cyclic nucleotide phosphodiesterases, type 4

Preferred Label : cyclic nucleotide phosphodiesterases, type 4;

MeSH definition : A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.;

MeSH synonym : phosphodiesterase iv; pde4 phosphodiesterases; phosphodiesterases, pde4; phosphodiesterase 4; phosphodiesterase-4; type 4 cyclic nucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase pde4 family;

MeSH hyponym : cyclic nucleotide phosphodiesterases, type 4A; cyclic nucleotide phosphodiesterases, type 4D3; cyclic nucleotide phosphodiesterases, type 4D; cyclic nucleotide phosphodiesterases, type 4B; cyclic nucleotide phosphodiesterases, type 4A5; cyclic nucleotide phosphodiesterases, type 4C; cAMP-Specific Phosphodiesterase 4A5; Phosphodiesterase 4A5, cAMP-Specific; cAMP Specific Phosphodiesterase 4A5; PDE4D3 Phosphodiesterase; Phosphodiesterase, PDE4D3; Phosphodiesterase 4C; Phosphodiesterase 4D; Phosphodiesterase 4A; Phosphodiesterase 4B;

CISMeF hyponym : EC 3.1.4.-;

MeSH Related Number : cyclic nucleotide phosphodiesterases, type 4A; cyclic nucleotide phosphodiesterases, type 4B; cyclic nucleotide phosphodiesterases, type 4A5; cyclic nucleotide phosphodiesterases, type 4D3; cyclic nucleotide phosphodiesterases, type 4C; cyclic nucleotide phosphodiesterases, type 4D; EC 3.1.4.17;

Registry Number MeSH : EC 3.1.4.17;

Related CAS MeSH : EC 3.1.4.- (Cyclic nucleotide phosphodiesterases, type 4A5); EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 4D3); EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 4C); EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 4D); EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 4A); EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 4B);

Is substance : O;

UNII : EC 3.1.4.17;

Details

Origin ID

D054703;

UMLS CUI

C0070829;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Phosphodiesterase 4a [OMIM gene]
- Phosphodiesterase 4b [OMIM gene]
- Phosphodiesterase 4c [OMIM gene]
- Phosphodiesterase 4d [OMIM gene]
- cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B [NCIt concept]
- phosphodiesterase 4A [HGNC gene]
- phosphodiesterase 4B [HGNC gene]
- phosphodiesterase 4C [HGNC gene]
- phosphodiesterase 4D [ORDO Gene]
- phosphodiesterase 4D [HGNC gene]
Indexing information
- (2,4-dibromo-3,6-dihydroxyphenyl)acetic acid [MeSH Supplementary Concept]
- 3-(4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)propanoic acid [MeSH Supplementary Concept]
- 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid [MeSH Supplementary Concept]
- 6-((3-((dimethylamino)carbonyl)phenyl)sulfonyl)-8-methyl-4-((3-methyloxyphenyl)amino)-3-quinolinecarboxamide [MeSH Supplementary Concept]
- GEBR-7b [MeSH Supplementary Concept]
- KW 4490 [MeSH Supplementary Concept]
- MK 0873 [MeSH Supplementary Concept]
- N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-N-methyl-3-(3-pyridyl)-2-propenamide [MeSH Supplementary Concept]
- Zl-n-91 compound [MeSH Supplementary Concept]
- hesperetin-7,3'-O-dimethylether [MeSH Supplementary Concept]
- moracin M [MeSH Supplementary Concept]
Record concept(s)
- cyclic nucleotide phosphodiesterases, type 4 [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4A [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4A5 [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4B [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4C [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4D [MeSH concept]
- cyclic nucleotide phosphodiesterases, type 4D3 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PDE4A protein, human [MeSH Supplementary Concept]
- PDE4B protein, human [MeSH Supplementary Concept]
- PDE4B protein, mouse [MeSH Supplementary Concept]
- PDE4B protein, rat [MeSH Supplementary Concept]
- PDE4C protein, human [MeSH Supplementary Concept]
- PDE4C protein, rat [MeSH Supplementary Concept]
- PDE4D protein, human [MeSH Supplementary Concept]
- PDE4D protein, mouse [MeSH Supplementary Concept]
- PDE4D protein, rat [MeSH Supplementary Concept]
- Pde4a protein, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- phosphodiesterase 4 inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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