Preferred Label : cyclic nucleotide phosphodiesterases, type 3;
MeSH definition : A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of
CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation
by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members
of this family are referred to as type 3A, and type 3B, and are each product of a
distinct gene. In addition multiple enzyme variants of each subtype can be produced
due to multiple alternative mRNA splicing.;
MeSH synonym : cGMP inhibited cyclic nucleotide phosphodiesterase; cGMP inhibited phosphodiesterase; cyclic nucleotide phosphodiesterase PDE3 family; phosphodiesterase III; cGMP-Inhibited cyclic nucleotide phosphodiesterase; cGMP-Inhibited phosphodiesterase; phosphodiesterase, cGMP-Inhibited;
MeSH hyponym : cyclic nucleotide phosphodiesterases, type 3A; cyclic nucleotide phosphodiesterases, type 3B; Phosphodiesterase 3B; Phosphodiesterase 3A;
MeSH Related Number : cyclic nucleotide phosphodiesterases, type 3B; EC 3.1.4.17;
Registry Number MeSH : EC 3.1.4.17;
Related CAS MeSH : EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 3B);
Is substance : O;
UNII : EC 3.1.4.17;
Origin ID : D054684;
UMLS CUI : C0292144;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
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A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of
CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation
by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members
of this family are referred to as type 3A, and type 3B, and are each product of a
distinct gene. In addition multiple enzyme variants of each subtype can be produced
due to multiple alternative mRNA splicing.
