rho-Associated kinases

Preferred Label : rho-Associated kinases;

MeSH definition : A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.;

MeSH synonym : coiled-coil kinase, rho-associated; protein kinases, rock; rho associated coiled coil kinase; rho associated kinase; rho kinase; rho-associated kinase; ROK Kinase; rho-Kinase; ROCK Protein Kinases; rho-Associated Coiled-Coil Kinase; rho associated kinases;

MeSH hyponym : rho-Associated kinase 2; rho-Associated kinase 1; rho Associated Kinase 1; ROCK-I Protein Kinase; ROCK I Protein Kinase; p160ROCK; rho-Associated Kinase beta; rho Associated Kinase beta; rho-Associated Protein Kinase beta; rho Associated Protein Kinase beta; rho-Associated Coiled-Coil Containing Protein Kinase 1; rho Associated Coiled Coil Containing Protein Kinase 1; rho Associated Kinase 2; rho-Associated Kinase alpha; rho Associated Kinase alpha; rho-Associated Coiled-Coil Containing Protein Kinase 2; rho Associated Coiled Coil Containing Protein Kinase 2; ROCK-II Protein Kinase; ROCK II Protein Kinase; p160 rhoA-Binding Kinase ROKalpha; p160 rhoA Binding Kinase ROKalpha; rho-Associated Protein Kinase alpha; rho Associated Protein Kinase alpha;

MeSH Related Number : rho-Associated kinase 1; rho-Associated kinase 2; EC 2.7.11.1;

Registry Number MeSH : EC 2.7.11.1;

Related CAS MeSH : EC 2.7.11.1 (rho-Associated kinase 1); EC 2.7.11.1 (rho-Associated kinase 2);

Is substance : O;

UNII : EC 2.7.11.1;

Details

Origin ID

D054460;

UMLS CUI

C0389995;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea [MeSH Supplementary Concept]
- 2-(1H-indazole-5-yl)amino-4-methoxy-6-piperazinotriazine [MeSH Supplementary Concept]
- 3-(4-pyridyl)-1H-indole [MeSH Supplementary Concept]
- 6-methoxy-N-(2-((1-methylpiperidin-4-yl)methoxy)-4-(1H-pyrazol-4-yl)phenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide [MeSH Supplementary Concept]
- 7-((4-hydroxy-1,2,4a,5-tetramethyl-6-oxo-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl)methoxy)chromen-2-one [MeSH Supplementary Concept]
- K-115 [MeSH Supplementary Concept]
- N-methyl-3-(((4-pyridin-4-ylbenzoyl)amino)methyl)benzamide [MeSH Supplementary Concept]
Record concept(s)
- rho-Associated kinase 1 [MeSH concept]
- rho-Associated kinase 2 [MeSH concept]
- rho-Associated kinases [MeSH concept]
Related MeSH Supplementary Concept(s)
- LET-502 protein, C elegans [MeSH Supplementary Concept]
- ROCK1 protein, human [MeSH Supplementary Concept]
- ROCK1 protein, rat [MeSH Supplementary Concept]
- ROCK2 protein, human [MeSH Supplementary Concept]
- ROCK2 protein, rat [MeSH Supplementary Concept]
- Rock1 protein, mouse [MeSH Supplementary Concept]
- Rock2 protein, mouse [MeSH Supplementary Concept]
- Rock2a protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients