MeSH definition : Integral membrane proteins and essential components of the gamma-secretase complex
that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID
BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE
with onset before age 65 years.;
Integral membrane proteins and essential components of the gamma-secretase complex
that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID
BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE
with onset before age 65 years.
Allowable qualifiers