Preferred Label : RecQ helicases;
MeSH definition : A family of structurally-related DNA helicases that play an essential role in the
maintenance of genome integrity. RecQ helicases were originally discovered in E COLI
and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic
mutations that result in loss of RecQ helicase activity gives rise to disorders that
are associated with CANCER predisposition and premature aging.;
MeSH synonym : helicases, recq; recq family of dna helicases; recq protein; RecQ Family of DNA Helicase; RecQ Helicase; Helicase, RecQ;
CISMeF synonym : EC 3.6.1.- (RecQ2 helicase); EC 3.6.1.- (RecQ3 helicase); EC 3.6.1.- (RecQ4 helicase); EC 3.6.1.- (RecQL helicase); EC 5.99.- (RecQ5 helicase);
MeSH hyponym : RecQ5 helicase; RecQ2 helicase; RecQL helicase; RecQ3 helicase; RecQ4 helicase; Helicase, RecQL; RECQL1 Helicase; Helicase, RECQL1; DNA Helicase RecQL; DNA-Dependent ATPase Q1; DNA Dependent ATPase Q1; ATP-Dependent DNA Helicase Q1; ATP Dependent DNA Helicase Q1; DNA Helicase Q1; RTS Helicase; Helicase, RTS; RecQL4 Helicase; Helicase, RecQL4; ATP-Dependent DNA Helicase Q4; ATP Dependent DNA Helicase Q4; DNA Helicase RecQL4; Helicase, RecQ5; RecQ5L Helicase; Helicase, RecQ5L; ATP-Dependent DNA Helicase Q5; ATP Dependent DNA Helicase Q5; Helicase, RecQ2; RecQL3 Helicase; Helicase, RecQL3; DNA Helicase, RecQ-like type 2; DNA Helicase, RecQ like type 2; Helicase, RecQ3; RecQL2 Helicase; Helicase, RecQL2;
CISMeF hyponym : EC 5.99.-;
MeSH Related Number : RecQL helicase; RecQ4 helicase; RecQ5 helicase; RecQ2 helicase; RecQ3 helicase; EC 3.6.4.12;
Registry Number MeSH : EC 3.6.1.-; EC 3.6.4.12;
Related CAS MeSH : EC 3.6.4.12 (RecQL helicase); EC 3.6.4.12 (RecQ4 helicase); EC 3.6.4.12 (RecQ5 helicase); EC 3.6.4.12 (RecQ2 helicase); EC 3.6.4.12 (RecQ3 helicase);
Is substance : O;
UNII : EC 3.6.4.12;
Origin ID : D053484;
UMLS CUI : C0084304;
Allowable qualifiers
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
A family of structurally-related DNA helicases that play an essential role in the
maintenance of genome integrity. RecQ helicases were originally discovered in E COLI
and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic
mutations that result in loss of RecQ helicase activity gives rise to disorders that
are associated with CANCER predisposition and premature aging.
