MeSH definition : A major and the second most common isoform of apolipoprotein E. In humans, Apo E4
differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine),
and exhibits a lower resistance to denaturation and greater propensity to form folded
intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.;
MeSH synonym : apo e epsilon 4; apolipoprotein e-4; apolipoprotein e 4; Apo E4; ApoE4; Apo E-4; apo e 4;
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4
differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine),
and exhibits a lower resistance to denaturation and greater propensity to form folded
intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.