MeSH definition : A family of cell surface receptors that signal via a conserved domain that extends
into the cell CYTOPLASM. The conserved domain is referred to as a death domain due
to the fact that many of these receptors are involved in signaling APOPTOSIS. Several
DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of
the activated receptors and through a complex series of interactions activate apoptotic
mediators such as CASPASES.; A family of cell surface receptors that signal via a conserved domain that extends
into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due
to the fact that many of these receptors are involved in APOPTOSIS signaling pathways.
Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains
of the activated receptors and through a complex series of interactions activate apoptotic
mediators such as CASPASES.;
MeSH synonym : receptors, death domain family; death domain receptors; receptors, dr family; dr family receptors; death receptors; Death Receptor; Receptor, Death;
A family of cell surface receptors that signal via a conserved domain that extends
into the cell CYTOPLASM. The conserved domain is referred to as a death domain due
to the fact that many of these receptors are involved in signaling APOPTOSIS. Several
DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of
the activated receptors and through a complex series of interactions activate apoptotic
mediators such as CASPASES. A family of cell surface receptors that signal via a conserved domain that extends
into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due
to the fact that many of these receptors are involved in APOPTOSIS signaling pathways.
Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains
of the activated receptors and through a complex series of interactions activate apoptotic
mediators such as CASPASES.
Allowable qualifiers