proto-oncogene proteins c-bcr

Preferred Label : proto-oncogene proteins c-bcr;

MeSH definition : Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.; A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.;

MeSH synonym : bcr proto-oncogene proteins; c bcr proteins; c-bcr proteins; c-bcr, proto-oncogene proteins; c-bcr proto-oncogene proteins; proto-oncogene protein bcr; proto-oncogene protein c-bcr; breakpoint cluster region protein; proto oncogene protein c bcr; c-bcr, proto-oncogene protein; c bcr proto oncogene proteins; proto oncogene protein bcr; proto-oncogene proteins, bcr; bcr proto oncogene proteins; Proto-Oncogene proteins, c-bcr; proto oncogene proteins c bcr;

CISMeF synonym : EC 2.7.1.37; proteins, c-bcr;

Registry Number MeSH : EC 2.7.11.1;

Is substance : O;

UNII : EC 2.7.11.1;

Details

Origin ID

D051562;

UMLS CUI

C0072449;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Proto-Oncogene proteins c-bcr [MeSH concept]
Related MeSH Supplementary Concept(s)
- BCR protein, human [MeSH Supplementary Concept]
- bcr protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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