Preferred Label : PTEN phosphohydrolase;
MeSH definition : A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate
various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION;
and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME
as well as NEOPLASTIC CELL TRANSFORMATION.; A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate
to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES;
CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE
and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.;
MeSH synonym : mutated in multiple advanced cancers 1 protein; phosphatase, pten; pten protein; phosphohydrolase, pten; pten phosphatase; phosphatase and tensin homologue on chromosome ten protein; mmac1 protein; PTEN Protein Phosphatase; Phosphatase, PTEN Protein; Protein Phosphatase, PTEN;
Registry Number MeSH : EC 3.1.3.67;
Is substance : O;
UNII : EC 3.1.3.67;
Origin ID : D051059;
UMLS CUI : C1530899;
Allowable qualifiers
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A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate
various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION;
and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME
as well as NEOPLASTIC CELL TRANSFORMATION.
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate
to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES;
CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE
and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
