methylmalonate-semialdehyde dehydrogenase (acylating)

Preferred Label : methylmalonate-semialdehyde dehydrogenase (acylating);

MeSH definition : An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.;

MeSH synonym : dehydrogenase, mmsa; Methylmalonic-Semialdehyde Dehydrogenase (Acylating); MMSDH; MMSA Dehydrogenase;

Registry Number MeSH : EC 1.2.1.27;

Is substance : O;

UNII : EC 1.2.1.27;

Details

Origin ID

D050646;

UMLS CUI

C0066394;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Methylmalonate-semialdehyde dehydrogenase (acylating) (substance) [SNOMED CT concept]
- methylmalonate-semialdehyde dehydrogenase (acylating) [SNOMED Notion]
Record concept(s)
- Methylmalonate-Semialdehyde dehydrogenase (Acylating) [MeSH concept]
Related MeSH Supplementary Concept(s)
- methylmalonate semialdehyde dehydrogenase deficiency [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Methylmalonate-semialdehyde dehydrogenase (acylating) (substance) [SNOMED CT concept]
- methylmalonate-semialdehyde dehydrogenase (acylating) [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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