mannose-binding protein-associated serine proteases

Preferred Label : mannose-binding protein-associated serine proteases;

MeSH definition : Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.;

MeSH synonym : serine protease, mbp-associated; masps; serine proteases, mbl-associated; masp proteases; mannose-binding protein-associated serine protease; mannose binding protein associated serine protease; mbp-associated serine protease; mbp associated serine protease; mannan-binding lectin serine proteases; mannan binding lectin serine proteases; mbl-associated serine proteases; mbl associated serine proteases; proteases, masp; MASP;

Related MeSH term : MASP-Related protein; MASP Related Protein; Protein, MASP-Related; MBP-Associated Serine Protease-Related Protein; MBP Associated Serine Protease Related Protein;

Registry Number MeSH : EC 3.4.21.-;

MeSH annotation : see SCR for organism-specific terms;

Is substance : O;

Details

Origin ID

D050606;

UMLS CUI

C0256616;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- MASP-Related protein [MeSH concept]
- Mannose-Binding Protein-Associated serine proteases [MeSH concept]
Related MeSH Supplementary Concept(s)
- MASP-1 protein, mouse [MeSH Supplementary Concept]
- MASP-2 protein, mouse [MeSH Supplementary Concept]
- MASP-3 protein, mouse [MeSH Supplementary Concept]
- MASP1 protein, human [MeSH Supplementary Concept]
- MASP2 deficiency [MeSH Supplementary Concept]
- MASP2 protein, human [MeSH Supplementary Concept]
- Masp1 protein, rat [MeSH Supplementary Concept]
- Masp2 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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