" /> homogentisate 1,2-dioxygenase - CISMeF





Preferred Label : homogentisate 1,2-dioxygenase;

MeSH definition : A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.;

MeSH synonym : acid oxidase, homogentisic; oxidase, homogentisate; homogentisate oxidase; 1,2-dioxygenase, homogentisate; dioxygenase, homogentisate; homogentisic acid oxidase; homogentisate dioxygenase; oxidase, homogentisic acid; homogentisate oxygenase; oxygenase, homogentisate; homogentisate 1,2 dioxygenase;

MeSH Related Number : 9029-49-6 (CRN);

Registry Number MeSH : EC 1.13.11.5;

Wikipedia link : https://en.wikipedia.org/wiki/Homogentisate 1,2-dioxygenase;

Is substance : O;

UNII : EC 1.13.11.5;

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A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

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25/07/2025


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