Preferred Label : homogentisate 1,2-dioxygenase;
MeSH definition : A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of
homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism
of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive
disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme
was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.;
MeSH synonym : acid oxidase, homogentisic; oxidase, homogentisate; homogentisate oxidase; 1,2-dioxygenase, homogentisate; dioxygenase, homogentisate; homogentisic acid oxidase; homogentisate dioxygenase; oxidase, homogentisic acid; homogentisate oxygenase; oxygenase, homogentisate; homogentisate 1,2 dioxygenase;
MeSH Related Number : 9029-49-6 (CRN);
Registry Number MeSH : EC 1.13.11.5;
Wikipedia link : https://en.wikipedia.org/wiki/Homogentisate 1,2-dioxygenase;
Is substance : O;
UNII : EC 1.13.11.5;
Origin ID : D050560;
UMLS CUI : C0062939;
Allowable qualifiers
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of
homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism
of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive
disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme
was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
