DNA-(Apurinic or apyrimidinic site) lyase

Preferred Label : DNA-(Apurinic or apyrimidinic site) lyase;

MeSH definition : A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.;

MeSH synonym : ap endonuclease; ap lyase; apurine-apyrimidine endonuclease; dna endonuclease, apurinic; endodeoxyribonuclease (apurinic or apyrimidinic); endonuclease, ap; endonuclease, apurine-apyrimidine; endonuclease, apurinic; apurine apyrimidine endonuclease; apurinic dna endonuclease; endonuclease, apurinic dna; apurinic endonuclease; dna lyase (apurinic or apyrimidinic);

Registry Number MeSH : EC 4.2.99.18;

Is substance : O;

UNII : EC 4.2.99.18;

Details

Origin ID

D043603;

UMLS CUI

C0950398;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 7-nitro-1H-indole-2-carboxylic acid [MeSH Supplementary Concept]
- N-(3-(benzo(d)thiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin-2-yl)acetamide [MeSH Supplementary Concept]
Record concept(s)
- DNA-(Apurinic or apyrimidinic site) lyase [MeSH concept]
Related MeSH Supplementary Concept(s)
- 8-oxoguanine DNA glycosylase 1, zebrafish [MeSH Supplementary Concept]
- ALKBH1 protein, mouse [MeSH Supplementary Concept]
- APEX1 protein, human [MeSH Supplementary Concept]
- APEX1 protein, rat [MeSH Supplementary Concept]
- APEX2 protein, human [MeSH Supplementary Concept]
- APLF protein, human [MeSH Supplementary Concept]
- APLF protein, mouse [MeSH Supplementary Concept]
- APN2 protein, S cerevisiae [MeSH Supplementary Concept]
- Abh1 protein, S pombe [MeSH Supplementary Concept]
- Apex1 protein, mouse [MeSH Supplementary Concept]
- Apex2 protein, mouse [MeSH Supplementary Concept]
- Apn1 protein, S pombe [MeSH Supplementary Concept]
- Apn2 protein, S pombe [MeSH Supplementary Concept]
- EXO-3 protein, C elegans [MeSH Supplementary Concept]
- NEIL2 protein, human [MeSH Supplementary Concept]
- NTG1 protein, S cerevisiae [MeSH Supplementary Concept]
- NTG2 protein, S cerevisiae [MeSH Supplementary Concept]
- Nth1 protein, S pombe [MeSH Supplementary Concept]
- apex1 protein, xenopus [MeSH Supplementary Concept]
- apex2 protein, Xenopus [MeSH Supplementary Concept]
- ribosomal protein P0, drosophila [MeSH Supplementary Concept]
- smx protein, streptococcus mutans [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Deoxyribonucleic acid-(apurinic or apyrimidinic site) lyase (substance) [SNOMED CT concept]
- deoxyribonuclease (apurinic or apyrimidinic) [SNOMED Notion]

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