1-alkyl-2-acetylglycerophosphocholine esterase

Preferred Label : 1-alkyl-2-acetylglycerophosphocholine esterase;

MeSH definition : A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.;

MeSH synonym : acetylhydrolase ii, paf; esterase, 1-alkyl-2-acetylglycerophosphocholine; factor hydrolase, platelet-activating; lipoprotein associated phospholipase a2; lipoprotein-associated phospholipase a(2); lp-pla(2); lp-pla2; paf acetylhydrolase; paf acetylhydrolase ii; paf 2 acetylhydrolase; paf 2 acylhydrolase; paf 2-acetylhydrolase; paf 2-acylhydrolase; platelet-activating factor hydrolase; 2-acetylhydrolase, paf; hydrolase, platelet-activating factor; platelet activating factor hydrolase; lipoprotein-associated phospholipase a2; phospholipase a2, lipoprotein-associated; lp pla2; acetylhydrolase, paf; 1 alkyl 2 acetylglycerophosphocholine esterase;

MeSH hyponym : platelet-activating factor acetylhydrolase IB; Platelet activating Factor Acetylhydrolase IB;

MeSH Related Number : platelet-activating factor acetylhydrolase IB; EC 3.1.1.47;

Registry Number MeSH : EC 3.1.1.47;

Related CAS MeSH : EC 3.1.1.47 (Platelet-activating factor acetylhydrolase IB);

MeSH annotation : /antag: coordinate with PHOSPHOLIPASE A2 INHIBITORS;

Wikipedia link : https://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine esterase;

Is substance : O;

UNII : EC 3.1.1.47;

Details

Origin ID

D043203;

UMLS CUI

C0914069;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- JMN4 compound [MeSH Supplementary Concept]
- WWL153 [MeSH Supplementary Concept]
Record concept(s)
- 1-Alkyl-2-acetylglycerophosphocholine esterase [MeSH concept]
- platelet-activating factor acetylhydrolase IB [MeSH concept]
Related MeSH Supplementary Concept(s)
- PAFAH1B1 protein, S cerevisiae [MeSH Supplementary Concept]
- PAFAH1B1 protein, human [MeSH Supplementary Concept]
- PAFAH1B2 protein, human [MeSH Supplementary Concept]
- PAFAH1B3 protein, human [MeSH Supplementary Concept]
- PAFAH1b2 protein, mouse [MeSH Supplementary Concept]
- PAFAH1b3 protein, mouse [MeSH Supplementary Concept]
- PLA2G7 protein, human [MeSH Supplementary Concept]
- Pafah1b1 protein, mouse [MeSH Supplementary Concept]
- Pafah2 protein, mouse [MeSH Supplementary Concept]
- Pla2g7 protein, mouse [MeSH Supplementary Concept]
- Platelet-Activating factor acetylhydrolase deficiency [MeSH Supplementary Concept]
- pafah1b1a protein, zebrafish [MeSH Supplementary Concept]
- pafah1b1b protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 1-alkyl-2-acetylglycerophosphocholine esterase [SNOMED Notion]
- 1-alkyl-2-acetylglycerophosphocholine esterase (substance) [SNOMED CT concept]
- Lipoprotein associated phospholipase A2 [LOINC component]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients