MeSH definition : QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They
inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation
4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and
a fluorine at the 6-position.;
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They
inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation
4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and
a fluorine at the 6-position.