vascular endothelial growth factor receptor-2

Preferred Label : vascular endothelial growth factor receptor-2;

MeSH definition : A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.;

MeSH synonym : fetal liver kinase 1; flk 1 protein; flk 1 receptor tyrosine kinase; flk-1 protein; flk-1 receptor tyrosine kinase; flk-1, vegf receptor; kdr, vegf receptor; kinase insert domain receptor; vegf receptor flk 1; vegf receptor flk-1; vegfr-2; vegf receptor kdr; fetal liver kinase-1; kdr tyrosine kinase; tyrosine kinase, kdr; vascular endothelial growth factor receptor 2;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.1;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D040301;

UMLS CUI

C0378796;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
Indexing information
- 1-(2-chloro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea [MeSH Supplementary Concept]
- 1-(2-fluoro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea [MeSH Supplementary Concept]
- 1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea [MeSH Supplementary Concept]
- 1-(4-(6-amino-5-(methoxyiminomethyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea [MeSH Supplementary Concept]
- 2,4-difluoro-5-(5-isopropyl-6-(5-(methylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-N-methoxybenzamide [MeSH Supplementary Concept]
- 2-methoxy-5-((6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl)amino)benzo-1,4-quinone [MeSH Supplementary Concept]
- 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol [MeSH Supplementary Concept]
- 3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one [MeSH Supplementary Concept]
- 4-((2-((4-chloro-3-(((1-methyl-2-pyrrolidinyl)methyl)oxy)phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide [MeSH Supplementary Concept]
- 4-(5-(6-(3-chlorophenylamino)pyrazin-2-yl)pyridin-3-ylamino)butan-1-ol [MeSH Supplementary Concept]
- 4-(benzothiazol-6-ylamino)-6-(benzyl-isopropyl-amino)-(1,3,5)triazin-2-ol [MeSH Supplementary Concept]
- 4-chloro-N-(1,1,3-trioxo-2,3-dihydrobenzo(d)isothiazol-4-yl)benzamide [MeSH Supplementary Concept]
- 5-(6-(5-(difluoro(methylsulfonyl)methyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide [MeSH Supplementary Concept]
- 5-(6-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-5-isopropylpyrrolo(2,1-f)(1,2,4)triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide [MeSH Supplementary Concept]
- 6-chloro-2-methoxy-N-(2-methoxybenzyl)acridin-9-amine [MeSH Supplementary Concept]
- CT-322 [MeSH Supplementary Concept]
- GU 81 compound [MeSH Supplementary Concept]
- N-(2,4-difluorophenyl)-N'-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-fluorophenyl)urea [MeSH Supplementary Concept]
- N-(2-fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)carbonylaminopyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide [MeSH Supplementary Concept]
- N-(4-((2-((cyclopropylcarbonyl)amino)imidazo(1,2-a)pyridin-6-yl)oxy)-3-fluorophenyl)-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide [MeSH Supplementary Concept]
- N-(5-(6-(3-chlorophenylamino)pyrazin-2-yl)pyridin-3-yl)-N',N'-dimethylethane-1,2-diamine [MeSH Supplementary Concept]
- N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamide [MeSH Supplementary Concept]
- N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide [MeSH Supplementary Concept]
- SKLB1002 [MeSH Supplementary Concept]
- SKLB1206 [MeSH Supplementary Concept]
- SU 1498 [MeSH Supplementary Concept]
- XL647 [MeSH Supplementary Concept]
- boletopsin C [MeSH Supplementary Concept]
Record concept(s)
- vascular endothelial growth factor Receptor-2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- KDR protein, Coturnix japonica [MeSH Supplementary Concept]
- KDR protein, human [MeSH Supplementary Concept]
- Kdr protein, mouse [MeSH Supplementary Concept]
- Kdr protein, rat [MeSH Supplementary Concept]
- arginyl-phenylalanyl-valyl-prolyl-aspartyl-glycyl-asparagyl-arginyl-isoleucine [MeSH Supplementary Concept]
- kdr protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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