Preferred Label : neuropilin-1;
MeSH definition : Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL)
and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS
3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with
plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by
the composition of the neuropilin dimer and the identity of other receptors complexed
with it. Neuropilin-1 is expressed in distinct patterns during neural development,
complementary to those described for NEUROPILIN-2.; A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL)
and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS
3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with
plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by
the composition of the neuropilin dimer and the identity of other receptors complexed
with it. Neuropilin-1 is expressed in distinct patterns during neural development,
complementary to those described for NEUROPILIN-2.;
MeSH synonym : npn-1 protein; receptor, sema iii; sema iii receptor; semaphorin iii receptor; nrp1 protein; a5 antigen; antigen, a5; npn 1 protein; neuropilin 1;
Registry Number MeSH : 144713-63-3;
Wikipedia link : https://en.wikipedia.org/wiki/Neuropilin 1;
Is substance : O;
Origin ID : D039942;
UMLS CUI : C0100804;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
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Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL)
and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS
3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with
plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by
the composition of the neuropilin dimer and the identity of other receptors complexed
with it. Neuropilin-1 is expressed in distinct patterns during neural development,
complementary to those described for NEUROPILIN-2.
A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL)
and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS
3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with
plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by
the composition of the neuropilin dimer and the identity of other receptors complexed
with it. Neuropilin-1 is expressed in distinct patterns during neural development,
complementary to those described for NEUROPILIN-2.
