MeSH definition : Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance
molecules during neural development and axonal outgrowth, and modulate VEGF-mediated
angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities,
and are distributed complementarily in regions of the developing nervous system. Neuropilins
are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial
growth factors, and may form hetero- or homodimers. They may also interact synergistically
with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities
and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like
domains in the extracellular portion of the molecule, while a MAM domain is essential
for SIGNAL TRANSDUCTION.;
MeSH synonym : neuropilin;
Wikipedia link : https://en.wikipedia.org/wiki/Neuropilin;
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance
molecules during neural development and axonal outgrowth, and modulate VEGF-mediated
angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities,
and are distributed complementarily in regions of the developing nervous system. Neuropilins
are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial
growth factors, and may form hetero- or homodimers. They may also interact synergistically
with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities
and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like
domains in the extracellular portion of the molecule, while a MAM domain is essential
for SIGNAL TRANSDUCTION.
Allowable qualifiers