Preferred Label : integrin alpha1beta1;
MeSH definition : Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely
expressed during development, but in the adult is the predominant laminin receptor
(RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance
of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found
in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis.
In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin
alpha1beta1 is also known as VLA-1 and CD49a-CD29.;
MeSH synonym : alpha1beta1, integrin; cd49a-cd29; vla-1; integrin alpha(1)beta(1); alpha1beta1 integrin; integrin, alpha1beta1;
Is substance : O;
Origin ID : D039222;
UMLS CUI : C0254616;
Allowable qualifiers
Record concept(s)
Semantic type(s)
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely
expressed during development, but in the adult is the predominant laminin receptor
(RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance
of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found
in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis.
In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin
alpha1beta1 is also known as VLA-1 and CD49a-CD29.