Preferred Label : integrin alpha6beta1;
MeSH definition : A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to
other cells via binding to LAMININ. It is involved in cell migration, embryonic development,
leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major
laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding
may activate a number of signal transduction pathways. Alternative splicing of the
cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation
of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.;
MeSH synonym : alpha 6 beta 1 integrin; i'c-iia, platelet glycoprotein; integrin alpha(6)beta(1); alpha6beta1, integrin; alpha6beta1 integrin; vla-6; vla 6; platelet glycoprotein i'c-iia; glycoprotein i'c-iia, platelet; platelet glycoprotein i'c iia; cd49f-cd29; cd49f cd29; integrin, alpha6beta1;
MeSH hyponym : integrin alpha6Bbeta1; integrin alpha6Abeta1; alpha6Bbeta1, Integrin; alpha6Abeta1, Integrin;
Is substance : O;
Origin ID : D039121;
UMLS CUI : C0246951;
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A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to
other cells via binding to LAMININ. It is involved in cell migration, embryonic development,
leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major
laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding
may activate a number of signal transduction pathways. Alternative splicing of the
cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation
of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
