" /> complement pathway, mannose-binding lectin - CISMeF





Preferred Label : complement pathway, mannose-binding lectin;

MeSH definition : Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.;

MeSH synonym : pathways, lectin-complement; pathway, lectin-complement; mannose binding lectin complement pathway; mannan-binding lectin complement pathway; lectin-complement pathway; lectin complement pathway; lectin-complement pathways; mannan binding lectin complement pathway; mannose-binding lectin complement pathway; mannan-binding lectin pathway (complement activation); lectin pathway, mannan-binding (complement activation); lectin pathways, mannan-binding (complement activation); mannan binding lectin pathway (complement activation); mannan-binding lectin pathways (complement activation); pathway, mannan-binding lectin (complement activation); pathways, mannan-binding lectin (complement activation); complement pathway, mannose binding lectin;

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Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

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27/04/2025


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