Preferred Label : complement pathway, mannose-binding lectin;
MeSH definition : Complement activation triggered by the interaction of microbial POLYSACCHARIDES with
serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED
SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT
C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading
to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.;
MeSH synonym : pathways, lectin-complement; pathway, lectin-complement; mannose binding lectin complement pathway; mannan-binding lectin complement pathway; lectin-complement pathway; lectin complement pathway; lectin-complement pathways; mannan binding lectin complement pathway; mannose-binding lectin complement pathway; mannan-binding lectin pathway (complement activation); lectin pathway, mannan-binding (complement activation); lectin pathways, mannan-binding (complement activation); mannan binding lectin pathway (complement activation); mannan-binding lectin pathways (complement activation); pathway, mannan-binding lectin (complement activation); pathways, mannan-binding lectin (complement activation); complement pathway, mannose binding lectin;
Origin ID : D037582;
UMLS CUI : C1138407;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Complement activation triggered by the interaction of microbial POLYSACCHARIDES with
serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED
SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT
C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading
to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
