Preferred Label : polyadenylation;
MeSH definition : The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER).
Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving
of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE
ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some
messenger RNAs, such as histone mRNA, is carried out by a different process that does
not include the addition of poly A as described here.;
MeSH synonym : polyadenylations;
Wikipedia link : https://en.wikipedia.org/wiki/Polyadenylation;
Origin ID : D026723;
UMLS CUI : C0949765;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER).
Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving
of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE
ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some
messenger RNAs, such as histone mRNA, is carried out by a different process that does
not include the addition of poly A as described here.
