Preferred Label : receptor, trka;
MeSH definition : A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN
3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation
in humans. Gene mutations that cause loss of receptor function are associated with
CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate
the protein-tyrosine kinase function are associated with tumorigenesis.;
MeSH synonym : c-trk, gp140; c-trk protein; c-trk, proto-oncogene products; gp140 c trk; gp140 c-trk; gp140(c-trk); neurotrophic tyrosine kinase receptor type 1; ntrk1 receptor; proto oncogene products c trk; proto oncogene protein trk; proto-oncogene products c-trk; proto-oncogene protein, trk; proto-oncogene protein trk; receptor, neurotrophic tyrosine kinase type 1; receptor, ntrk1; trk proto oncogene protein; trk, proto-oncogene protein; trk proto-oncogene protein; trka receptor; trk1 transforming tryrosine kinase; c trk protein; p140-trka; p140 trka;
CISMeF synonym : EC 2.7.1.112;
Registry Number MeSH : EC 2.7.10.1;
MeSH annotation : DF: RECEPT TRKA;
Is substance : O;
UNII : EC 2.7.10.1;
Origin ID : D020917;
UMLS CUI : C0072482;
Allowable qualifiers
- Indexing information
- KRC-108 [MeSH Supplementary Concept]
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN
3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation
in humans. Gene mutations that cause loss of receptor function are associated with
CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate
the protein-tyrosine kinase function are associated with tumorigenesis.
