MeSH definition : Non-hematopoietic cells, with extensive dendritic processes, found in the primary
and secondary follicles of lymphoid tissue (the B cell zones). They are different
from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL
STEM CELLS and are negative for class II MHC antigen and do not process or present
antigen like the conventional dendritic cells do. Instead, follicular dendritic cells
have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY
COMPLEXES on their surfaces for long periods for recognition by B-CELLS.;
Non-hematopoietic cells, with extensive dendritic processes, found in the primary
and secondary follicles of lymphoid tissue (the B cell zones). They are different
from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL
STEM CELLS and are negative for class II MHC antigen and do not process or present
antigen like the conventional dendritic cells do. Instead, follicular dendritic cells
have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY
COMPLEXES on their surfaces for long periods for recognition by B-CELLS.