Preferred Label : surface plasmon resonance;
MeSH definition : A biosensing technique in which biomolecules capable of binding to specific analytes
or ligands are first immobilized on one side of a metallic film. Light is then focused
on the opposite side of the film to excite the surface plasmons, that is, the oscillations
of free electrons propagating along the film's surface. The refractive index of light
reflecting off this surface is measured. When the immobilized biomolecules are bound
by their ligands, an alteration in surface plasmons on the opposite side of the film
is created which is directly proportional to the change in bound, or adsorbed, mass.
Binding is measured by changes in the refractive index. The technique is used to study
biomolecular interactions, such as antigen-antibody binding.;
MeSH synonym : plasmon resonances, surface; resonances, surface plasmon; plasmon resonance, surface; resonance, surface plasmon; surface plasmon resonances;
MeSH annotation : do not confuse with plasmon, extrachromosomal genetic material;
Wikipedia link : https://en.wikipedia.org/wiki/Surface plasmon resonance;
Origin ID : D020349;
UMLS CUI : C0597731;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A biosensing technique in which biomolecules capable of binding to specific analytes
or ligands are first immobilized on one side of a metallic film. Light is then focused
on the opposite side of the film to excite the surface plasmons, that is, the oscillations
of free electrons propagating along the film's surface. The refractive index of light
reflecting off this surface is measured. When the immobilized biomolecules are bound
by their ligands, an alteration in surface plasmons on the opposite side of the film
is created which is directly proportional to the change in bound, or adsorbed, mass.
Binding is measured by changes in the refractive index. The technique is used to study
biomolecular interactions, such as antigen-antibody binding.
