MeSH definition : The naturally occurring or experimentally induced replacement of one or more AMINO
ACIDS in a protein with another. If a functionally equivalent amino acid is substituted,
the protein may retain wild-type activity. Substitution may also diminish, enhance,
or eliminate protein function. Experimentally induced substitution is often used to
study enzyme activities and binding site properties.;
The naturally occurring or experimentally induced replacement of one or more AMINO
ACIDS in a protein with another. If a functionally equivalent amino acid is substituted,
the protein may retain wild-type activity. Substitution may also diminish, enhance,
or eliminate protein function. Experimentally induced substitution is often used to
study enzyme activities and binding site properties.
Allowable qualifiers