MeSH definition : A family of protein serine/threonine kinases which act as intracellular signalling
intermediates. Ribosomal protein S6 kinases are activated through phosphorylation
in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.
Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased
expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of
this class of kinases can act on a number of substrates within the cell. The immunosuppressant
SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.;
A family of protein serine/threonine kinases which act as intracellular signalling
intermediates. Ribosomal protein S6 kinases are activated through phosphorylation
in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.
Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased
expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of
this class of kinases can act on a number of substrates within the cell. The immunosuppressant
SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.