Preferred Label : eif-2 kinase;
MeSH definition : A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced
by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on
several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation
of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition
of protein synthesis.;
MeSH synonym : double stranded rna-dependent kinase (dsl); dsrna activated inhibitor; dsrna dep protein kinase; dsrna-activated inhibitor; dsrna-dep protein kinase; eif 2alpha kinase; eif-2alpha kinase; erf, eif 2 recycling factor; erf, eif-2 recycling factor; heme controlled repressor; heme controlled translational repressor; heme-controlled inhibitor; hemin controlled repressor; hemin-controlled translational repressor; inhibitor, dsrna-activated; inhibitor, heme-controlled; kinase, dai protein; kinase, dsrna-dep protein; kinase, eif-2; kinase, eif-2alpha; kinase, heme-regulated eif-2alpha; kinase, p65; kinase, rna-dependent protein; pkr, protein kinase; protein kinase, dsrna-dep; protein kinase pkr; protein kinase, self-phosphorylating; p68 protein kinase; repressor, hemin-controlled translational; rna dependent protein kinase; tik kinase; translational repressor, heme-controlled; controlled repressor, heme; double stranded rna-dependent eif-2 alpha protein kinase; hemin controlled translational repressor; translational repressor, hemin-controlled; p65 kinase; p68 kinase; kinase, p68; kinase, p68 protein; protein kinase, p68; kinase pkr, protein; protein kinase, rna activated; rna-dependent protein kinase; protein kinase, rna-dependent; self-phosphorylating protein kinase; kinase, self-phosphorylating protein; self phosphorylating protein kinase; kinase, tik; dai protein kinase; protein kinase, dai; double stranded rna dependent eif 2 alpha protein kinase; eukaryotic initiation factor 2alpha kinase; repressor, heme controlled; heme controlled inhibitor; heme-controlled translational repressor; repressor, heme-controlled translational; heme-regulated eif-2alpha kinase; heme regulated eif 2alpha kinase; eif-2alpha kinase, heme-regulated; controlled repressor, hemin; repressor, hemin controlled; eIF 2 kinase;
CISMeF synonym : EC 2.7.1.37;
Registry Number MeSH : EC 2.7.11.1;
Is substance : O;
UNII : EC 2.7.11.1;
Origin ID : D019892;
UMLS CUI : C0058980;
Allowable qualifiers
- Indexing information
- imoxin [MeSH Supplementary Concept]
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced
by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on
several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation
of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition
of protein synthesis.
