cromakalim - CISMeF

Preferred Label : cromakalim;

MeSH definition : A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352);

CISMeF synonym : 94535-50-9 (Levcromakalim);

MeSH hyponym : BRL-38227; lemakalim; cromakalim, (3R-cis)-Isomer; cromakalim, (3R-trans)-Isomer; levcromakalim; cromakalim, (3S-cis)-Isomer; cromakalim, (trans)-Isomer; BRL-34915; BRL-38226; BRL 38226; BRL38226; Cromakalim, (3S-trans)-Isomer; BRL 38227; BRL38227;

MeSH CAS label : 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-( -)-;

MeSH Related Number : levcromakalim; cromakalim, (3R-trans)-Isomer; cromakalim, (3S-cis)-Isomer; cromakalim, (trans)-Isomer; cromakalim, (3R-cis)-Isomer; 148811-93-2 ((3R-cis)-isomer); 148811-94-3 ((3S-cis)-isomer); 150871-62-8 (cpd w/out isomeric designation); 86776-67-2 ((trans)-isomer); 94470-67-4 (Cromakalim); 94535-50-9 ((3S-trans)-isomer); 94535-51-0 ((3R-trans)-isomer); RW7PN4BLDJ;

Registry Number MeSH : 94470-67-4;

Related CAS MeSH : 94535-51-0 (Cromakalim, (3R-trans)-Isomer); 148811-94-3 (Cromakalim, (3S-cis)-Isomer); 86776-67-2 (Cromakalim, (trans)-Isomer); 148811-93-2 (Cromakalim, (3R-cis)-Isomer); RW7PN4BLDJ (Levcromakalim);

Wikipedia link : https://en.wikipedia.org/wiki/Cromakalim;

Is substance : O;

UNII : 0G4X367WA3;

InChIKey : TVZCRIROJQEVOT-CABCVRRESA-N;

Details

Origin ID

D019806;

UMLS CUI

C0056506;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Levcromakalim [NCIt concept]
Currated CISMeF NLP mapping
- Cromakalim [NCIt concept]
Pharmacological action(s)
- antihypertensive agents [MeSH Descriptor]
- bronchodilator agents [MeSH Descriptor]
- parasympatholytics [MeSH Descriptor]
- peripheral nervous system agents [MeSH Descriptor]
- vasodilator agents [MeSH Descriptor]
Record concept(s)
- BRL-34915 [MeSH concept]
- BRL-38226 [MeSH concept]
- BRL-38227 [MeSH concept]
- cromakalim [MeSH concept]
- cromakalim, (3R-cis)-Isomer [MeSH concept]
- cromakalim, (3R-trans)-Isomer [MeSH concept]
- cromakalim, (3S-cis)-Isomer [MeSH concept]
- cromakalim, (trans)-Isomer [MeSH concept]
- lemakalim [MeSH concept]
- levcromakalim [MeSH concept]
Related MeSH Supplementary Concept(s)
- 1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea [MeSH Supplementary Concept]
- EMD 57970 [MeSH Supplementary Concept]
- EMD 60480 [MeSH Supplementary Concept]
- S 870121 [MeSH Supplementary Concept]
- S 872342 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cromakalim [NCIt concept]

Keyword's position in hierarchy(ies) :

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